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MATHEW J. PALAKAL , Ph.D. Associate Dean, Graduate Studies and Research Director, Informatics Research Institute 535 W. Michigan St. IT 477 Indianapolis, IN 46202 Phone: (317) 278-7689 Fax: (317) 278-4140 mpalakal@iupui.edu |
| RESEARCH |
| The biomedical literature databases continue to grow rapidly with vital information that is important for conducting sound biomedical research. BioMap is an attempt to create a scalable knowledgebase of biological relationships from vast amount of literature data. The development of BioMap system addresses several innovative research issues related to knowledge discovery from literature documents and real-time, interactive access of this knowledge. Specific problems that are being investigated are: discovering explicit, implicit and directional relationships among biological entities from abstracts and full text documents; discovering both explicit and implicit protein-protein interactions and computationally validating these interactions; and, obtaining novel pathways associated with specific diseases in question. Protein-protein, gene-protein, disease-drug interactions are examples of biological associations that are automatically discovered from large number of literature documents. BioMap can discover interactions in user specified biomedical problem domains such as inflammatory diseases, regenerative biology, cancer, etc., and provide a user-centric view of the interactions. |